GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2274459 | 1 | rs66670017 | chr6:33763563 | IP6K3 | chr6:33689443-33714762:- | 0.41 | 6.7 | 6.04E-11 | Obesity (extreme) |
| THCA | cis | rs8030605 | 1 | rs66670902 | chr15:56375132 | MNS1 | chr15:56720929-56757335:- | -0.27 | -3.96 | 8.54E-5 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs66670902 | chr15:56375132 | TEX9 | chr15:56657644-56738071:+ | -0.36 | -6.19 | 1.3E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs4660306 | 1 | rs6667191 | chr1:45982844 | AKR1A1 | chr1:46016498-46035720:+ | -0.14 | -3.8 | 0.000161 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6667191 | chr1:45982844 | CCDC163P | chr1:45960581-45965646:- | -1.11 | -31.35 | 5.06E-118 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6667191 | chr1:45982844 | MUTYH | chr1:45794915-45806142:- | 0.22 | 5.11 | 4.75E-7 | Homocysteine levels |
| THCA | cis | rs4660306 | 1 | rs6667191 | chr1:45982844 | PRDX1 | chr1:45976708-45987609:- | -0.4 | -10.1 | 7.11E-22 | Homocysteine levels |
| THCA | cis | rs9782955 | 1 | rs6668242 | chr1:236001779 | LYST | chr1:235824345-236046940:- | -0.32 | -9.69 | 2.17E-20 | Systemic lupus erythematosus |
| THCA | cis | rs2275426 | 1 | rs6668284 | chr1:46354510 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.11 | 6.85E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6668284 | chr1:46354510 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.04 | 6.11E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6668284 | chr1:46354510 | MMACHC | chr1:45965856-45976737:+ | -0.2 | -4.41 | 1.3E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6668284 | chr1:46354510 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.54 | 1.77E-16 | Body mass index |
| THCA | cis | rs683250 | 1 | rs666845 | chr11:83277544 | CCDC90B | chr11:82972506-82997414:- | 0.16 | 3.86 | 0.00013 | Subcortical brain region volumes |
| THCA | cis | rs12134133 | 1 | rs6668683 | chr1:207459191 | CD55 | chr1:207494817-207534309:+ | 0.19 | 7.72 | 6.89E-14 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs7537765 | 1 | rs6669371 | chr1:11882142 | CLCN6 | chr1:11866207-11907674:+ | 0.16 | 3.4 | 0.000741 | QRS complex (12-leadsum) |